Placental growth factor deficiency is associated with impaired cerebral vascular development in mice.

ABSTRACT:

Study hypothesis

Placental growth factor (PGF) is expressed in the developing mouse brain and contributes to vascularization and vessel patterning.

Study finding

PGF is dynamically expressed in fetal mouse brain, particularly forebrain, and is essential for normal cerebrovascular development.

What is known already

PGF rises in maternal plasma over normal human and mouse pregnancy but is low in many women with the acute onset hypertensive syndrome, pre-eclampsia (PE). Little is known about the expression of PGF in the fetus during PE. Pgf  (-/-) mice appear normal but recently cerebral vascular defects were documented in adult Pgf  (-/-) mice.

Study design, samples/materials, methods

Here, temporal-spatial expression of PGF is mapped in normal fetal mouse brains

SUBMITTER: Luna RL 

PROVIDER: S-EPMC4733225 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature