GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.

ABSTRACT:

Study hypothesis

We hypothesized that Runt-related transcription factor 2 (RUNX2), matrix metalloproteinase (MMP)2 and MMP9 are involved in basal and gonadotrophin-releasing hormone (GnRH)-induced human extravillous trophoblast (EVT) cell invasion.

Study finding

Our finding indicates that GnRH-induced RUNX2 expression enhances the invasive capacity of EVT cells by modulating the expression of MMP2 and MMP9.

What is known already

GnRH is expressed in first-trimester placenta and exerts pro-invasive effects on EVT cells in vitro. RUNX2 regulates MMP2 and MMP9 expression and is often associated with invasive phenotypes.

Study design, samples/materials, methods

First-trimester human placenta (n = 9) was obtained from women undergoing elective termination of pregnan

SUBMITTER: Peng B 

PROVIDER: S-EPMC4733226 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature