Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials.

ABSTRACT:

Background

Circulating amino acids, such as branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs), have been associated with diabetes risk; however, little is known about how a long-term dietary intervention for weight loss affects circulating amino acids.

Objectives

We examined the effects of weight-loss diets on long-term changes in plasma amino acids and the associations of these changes with weight loss and the improvement of insulin resistance.

Design

We repeatedly measured plasma amino acid profiles over 2 y in overweight or obese participants from 2 randomized, dietary intervention, weight-loss trials [774 subjects from the POUNDS LOST (Preventing Overweight Using Novel Dietary Strategies Trial) and 318 subjects from the DIRECT (Dietary Interventio

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC4733257 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature