Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals.

ABSTRACT:

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There is a need for effective, early post-trauma preventive interventions for post-traumatic stress disorder (PTSD). Attenuating amygdala hyperreactivity early post-trauma, a likely PTSD vulnerability factor, may decrease PTSD risk. Since oxytocin modulates amygdala reactivity to emotional stimuli, oxytocin administration early post-trauma may be a promising candidate for PTSD prevention. In a randomized double-blind placebo-controlled fMRI study, we investigated effects of a single intranasal oxytocin administration (40 IU) on amygdala reactivity to happy, neutral and fearful faces in 41 recently trauma-exposed men and women showing moderate to high distress after initial post-trauma screening. We explored treatment interactions with sex. Participants were scanned withi

SUBMITTER: Frijling JL 

PROVIDER: S-EPMC4733344 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature