Forelimb muscle plasticity following unilateral cervical spinal cord injury.

ABSTRACT:

Introduction

Motor dysfunction and muscle atrophy are well documented in the lower extremity after spinal cord injury. However, the extent and time course of myoplastic changes in forelimb musculature is not clear.

Methods

Forelimb muscle morphology and fiber type were evaluated after high cervical hemilesion injury in rats.

Results

There was significant atrophy of the ipsilateral extensor carpi radialis longus (ECRL) muscle at 2 weeks postinjury, which was subsequently reversed at 8 weeks postinjury. The triceps muscle showed minimal evidence of atrophy after spinal injury. No significant changes in fiber type were observed.

Conclusions

These findings indicate a robust capacity for spontaneous myoplasticity after C2 hemisection injury but highlight differentia

SUBMITTER: Gonzalez-Rothi EJ 

PROVIDER: S-EPMC4733411 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature