Test for rare variants by environment interactions in sequencing association studies.

ABSTRACT: We consider in this article testing rare variants by environment interactions in sequencing association studies. Current methods for studying the association of rare variants with traits cannot be readily applied for testing for rare variants by environment interactions, as these methods do not effectively control for the main effects of rare variants, leading to unstable results and/or inflated Type 1 error rates. We will first analytically study the bias of the use of conventional burden-based tests for rare variants by environment interactions, and show the tests can often be invalid and result in inflated Type 1 error rates. To overcome these difficulties, we develop the interaction sequence kernel association test (iSKAT) for assessing rare variants by environment interactions. The pr

SUBMITTER: Lin X 

PROVIDER: S-EPMC4733434 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature