Use of Renally Inappropriate Medications in Older Veterans: A National Study.

ABSTRACT:

Objectives

To determine how many ambulatory older adults with chronic kidney disease receive medications that are contraindicated or dosed excessively given their level of renal function.

Design

Cross-sectional retrospective study.

Setting

U.S. Department of Veterans Affairs (VA) clinics.

Participants

Individuals aged 65 and older with a creatinine clearance (CrCl) of 15 to 49 mL/min (N = 83,850; mean age 80; 96% male).

Measurements

Forty medications that require dose adjustment or are contraindicated in people with impaired renal function were examined. Medication use and CrCl (calculated using the Cockroft-Gault equation) were assessed using VA pharmacy, laboratory, and other data sources as of October 2007.

Results

Thirteen percent of older vet

SUBMITTER: Chang F 

PROVIDER: S-EPMC4733653 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature