Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus.

ABSTRACT:

Objective

To evaluate the utility of zinc transporter-8 (ZnT8) in the improvement of type 1 diabetes mellitus (T1DM) diagnosis and prediction, and to explore whether ZnT8 is a potential therapeutic target in T1DM.

Data sources

A search was conducted within the medical database PubMed for relevant articles published from 2001 to 2015. The search terms are as follows: "ZnT8," "type 1 diabetes," "latent autoimmune diabetes in adults," "type 2 diabetes," "islet autoantibodies," "zinc supplement," "T cells," "β cell," "immune therapy." We also searched the reference lists of selected articles.

Study selection

English-language original articles and critical reviews concerning ZnT8 and the clinical applications of islet autoantibodies in diabetes were reviewed.

Results

SUBMITTER: Yi B 

PROVIDER: S-EPMC4733793 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature