Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.

ABSTRACT:

Unlabelled

Lifelong antiretroviral therapy (ART) for HIV-1 does not diminish the established latent reservoir. A possible cure approach is to reactivate the quiescent genome from latency and utilize immune responses to eliminate cells harboring reactivated HIV-1. It is not known whether antibodies within HIV-1-infected individuals can recognize and eliminate cells reactivated from latency through antibody-dependent cellular cytotoxicity (ADCC). We found that reactivation of HIV-1 expression in the latently infected ACH-2 cell line elicited antibody-mediated NK cell activation but did not result in antibody-mediated killing. The lack of CD4 expression on these HIV-1 envelope (Env)-expressing cells likely resulted in poor recognition of CD4-induced antibody epitopes on Env. To examin

SUBMITTER: Lee WS 

PROVIDER: S-EPMC4733999 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature