A multi-objective optimization approach accurately resolves protein domain architectures.

ABSTRACT:

Motivation

Given a protein sequence and a number of potential domains matching it, what are the domain content and the most likely domain architecture for the sequence? This problem is of fundamental importance in protein annotation, constituting one of the main steps of all predictive annotation strategies. On the other hand, when potential domains are several and in conflict because of overlapping domain boundaries, finding a solution for the problem might become difficult. An accurate prediction of the domain architecture of a multi-domain protein provides important information for function prediction, comparative genomics and molecular evolution.

Results

We developed DAMA (Domain Annotation by a Multi-objective Approach), a novel approach that identifies architectures th

SUBMITTER: Bernardes JS 

PROVIDER: S-EPMC4734041 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature