CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.

ABSTRACT:

Purpose

Complement factor I (CFI) plays an important role in complement activation pathways and is known to affect the development of uveitis. The present study was performed to investigate the existence of an association between CFI genetic polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome.

Methods

A total of 100 patients diagnosed with VKH syndrome and 300 healthy controls were recruited for the study. Two milliliters of peripheral blood were collected in a sterile anticoagulative tube. CFI-rs7356506 polymorphisms were genotyped using Sequenom MassARRAY technology. Allele and genotype frequencies were compared between patients and controls using a χ(2) test. The analyses were stratified for recurrent status, complicated cataract status, and steroid-sensitive status.

SUBMITTER: Dai ML 

PROVIDER: S-EPMC4734154 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature