Kernel Architecture of the Genetic Circuitry of the Arabidopsis Circadian System.

ABSTRACT: A wide range of organisms features molecular machines, circadian clocks, which generate endogenous oscillations with ~24 h periodicity and thereby synchronize biological processes to diurnal environmental fluctuations. Recently, it has become clear that plants harbor more complex gene regulatory circuits within the core circadian clocks than other organisms, inspiring a fundamental question: are all these regulatory interactions between clock genes equally crucial for the establishment and maintenance of circadian rhythms? Our mechanistic simulation for Arabidopsis thaliana demonstrates that at least half of the total regulatory interactions must be present to express the circadian molecular profiles observed in wild-type plants. A set of those essential interactions is called herein a ker

SUBMITTER: Foo M 

PROVIDER: S-EPMC4734688 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature