Proteome-Wide Identification of Lysine Succinylation in the Proteins of Tomato (Solanum lycopersicum).

ABSTRACT: Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in Escherichia coli, yeast, Toxoplasma gondii, HeLa cells, and mouse liver. Interestingly, only a few sites of lysine succinylation have been detected in plants to date. In this study, we identified 347 sites of lysine succinylation in 202 proteins in tomato by using high-resolution mass spectrometry. Succinylated proteins are implicated in the regulation of diverse metabolic processes, including chloroplast and mitochondrial metabolism. Bioinformatic analysis showed that succinylated proteins are evolutionarily conserved and involved in various cellular functions such as metabolism

SUBMITTER: Jin W 

PROVIDER: S-EPMC4734689 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature