Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study.

ABSTRACT:

Aim

To study the effectiveness of melatonin vs placebo in children with functional dyspepsia (FD).

Methods

The study was conducted as a double blind, randomized, placebo controlled crossover trial. Subjects were aged 8-17 years and diagnosed with FD based on Rome III criteria. All subjects had failed to respond to 4 wk of acid suppression. Subjects receive a continuous two weeks of placebo and a continuous two weeks of melatonin in an order blinded to the participant and the study team. A Global Clinical Score was obtained to assess changes in abdominal pain. Pain was self-reported to be worse (grade 1), no change (grade 2), moderate improvement (grade 3), good (grade 4; minimal pain and not interfering with daily activities), or excellent (grade 5; no pain), respectively. A

SUBMITTER: Zybach K 

PROVIDER: S-EPMC4734949 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature