Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives.

ABSTRACT: Gastric cancer is a global health burden and has the highest incidence in East Asia. This disease is complex in nature because it arises from multiple interactions of genetic, local environmental, and host factors, resulting in biological heterogeneity. This genetic intricacy converges on molecular characteristics reflecting the pathophysiology, tumor biology, and clinical outcome. Therefore, understanding the molecular characteristics at a genomic level is pivotal to improving the clinical care of patients with gastric cancer. A recent landmark study, The Cancer Genome Atlas (TCGA) project, showed the molecular landscape of gastric cancer through a comprehensive molecular evaluation of 295 primary gastric cancers. The proposed molecular classification divided gastric cancer into four subt

SUBMITTER: Choi YY 

PROVIDER: S-EPMC4734963 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature