Comparison of activity to stimulate mucosal IgA production between Leuconostoc mesenteroides strain NTM048 and type strain JCM6124 in mice.

ABSTRACT: The effects of Leuconostoc mesenteroides strain NTM048 and type strain JCM6124(T) on the murine immune system were characterized. Although the bacterial cells and exopolysaccharides of each strain induced immunoglobulin A production in Peyer's patch cells, the effects of NTM048 were more potent than those of JCM6124(T). Oral administration of the cells of each strain increased the fecal immunoglobulin A content in NTM048-treated mice, but not in JCM6124(T)-treated mice. A flow cytometric analysis showed that the CD4(+) T-cell populations in the mouse spleens tended to increase in the NTM048 group. These results suggest that immunomodulating ability is characteristic of strain NTM048.

SUBMITTER: Matsuzaki C 

PROVIDER: S-EPMC4735033 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature