Determinants of bacteriological outcomes in exacerbations of chronic obstructive pulmonary disease.

ABSTRACT:

Purpose

Changes in sputum microbiology following antibiotic treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), including patterns of bacteriological relapse and superinfection are not well understood. Sputum microbiology at exacerbation is not routinely performed, but pathogen presence and species are determinants of outcomes. Therefore, we determined whether baseline clinical factors could predict the presence of bacterial pathogens at exacerbation. Bacterial eradication at end of treatment (EOT) is associated with clinical resolution of exacerbation. We determined the clinical, microbiological and therapeutic factors that were associated with bacteriological eradication in AECOPD at EOT and in the following 8 weeks.

Methods

Sputum bacteriol

SUBMITTER: Sethi S 

PROVIDER: S-EPMC4735236 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature