Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.

ABSTRACT: Mitochondria are an essential source of ATP for cellular function, but when damaged, mitochondria generate a plethora of stress signals, which lead to cellular dysfunction and eventually programmed cell death. Thus, a major component of maintaining cellular homeostasis is the recognition and removal of dysfunctional mitochondria through autophagy-mediated degradation, i.e., mitophagy. Mitophagy further constitutes a developmental program, and undergoes a high degree of crosstalk with apoptosis. Reduced mitochondrial quality control is linked to disease pathogenesis, suggesting the importance of process elucidation as a clinical target. Recent work has revealed multiple mitophagy programs that operate independently or undergo crosstalk, and require modulated autophagy receptor activities at

SUBMITTER: Hamacher-Brady A 

PROVIDER: S-EPMC4735260 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature