Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection.

ABSTRACT: Clostridium difficile epidemiology has changed in recent years, with the emergence of highly virulent types associated with severe infections, high rates of recurrences and mortality. Antibiotic resistance plays an important role in driving these epidemiological changes and the emergence of new types. While clindamycin resistance was driving historical endemic types, new types are associated with resistance to fluoroquinolones. Furthermore, resistance to multiple antibiotics is a common feature of the newly emergent strains and, in general, of many epidemic isolates. A reduced susceptibility to antibiotics used for C. difficile infection (CDI) treatment, in particular to metronidazole, has recently been described in several studies. Furthermore, an increased number of strains show resistan

SUBMITTER: Spigaglia P 

PROVIDER: S-EPMC4735502 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature