Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira.

ABSTRACT: Leptospirosis, caused by pathogenic Leptospira spp., has recently been recognized as an emerging infectious disease worldwide. Despite its severity and global importance, knowledge about the molecular pathogenesis and virulence evolution of Leptospira spp. remains limited. Here we sequenced and analyzed 102 isolates representing global sources. A high genomic variability were observed among different Leptospira species, which was attributed to massive gene gain and loss events allowing for adaptation to specific niche conditions and changing host environments. Horizontal gene transfer and gene duplication allowed the stepwise acquisition of virulence factors in pathogenic Leptospira evolved from a recent common ancestor. More importantly, the abundant expansion of specific virulence-relate

SUBMITTER: Xu Y 

PROVIDER: S-EPMC4735792 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature