Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study.

ABSTRACT:

Background

Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to evaluate the contribution of the RAGE axis to early and late immune responses.

Methods

We enrolled 16 patients with severe trauma together with 10 patients after major abdominal surgery and 10 healthy volunteers. Blood samples were taken on admission and every 48 h for a total of 8 days. Plasma concentrations of various RAGE ligands as well as RAGE isoforms and IL-6 were measured by ELISA. Monocyte surface expression of RAGE and HLA-DR was assessed by flow cytome

SUBMITTER: Uhle F 

PROVIDER: S-EPMC4736010 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature