Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances.

ABSTRACT: The inflammation theory of depression, proposed over 20years ago, was influenced by early studies on T cell responses and since then has been a stimulus for numerous research projects aimed at understanding the relationship between immune function and depression. Observational studies have shown that indicators of immunity, especially C reactive protein and proinflammatory cytokines, such as interleukin 6, are associated with an increased risk of depressive disorders, although the evidence from randomized trials remains limited and only few studies have assessed the interplay between innate and adaptive immunity in depression. In this paper, we review current knowledge on the interactions between central and peripheral innate and adaptive immune molecules and the potential role of immune-r

SUBMITTER: Haapakoski R 

PROVIDER: S-EPMC4736094 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature