Gene expression profiling of rubella virus infected primary endothelial cells of fetal and adult origin.

ABSTRACT:

Background

Rubella virus (RV) infection is usually a mild illness in children and adults. However, maternal infection during the first trimester of pregnancy can lead to congenital rubella syndrome (CRS) in the infant. Fetuses with CRS show damage to the endothelium of the heart and blood vessels; thus, it has been speculated that the clinical manifestations associated with CRS may be a result of endothelial cells persistently infected with RV. Here, we compared the effects of RV infection on gene expression in primary endothelial cells of fetal (HUVEC) and of adult (HSaVEC) origin by transcriptional profiling.

Results

More than 75 % of the genes differentially regulated following RV infection were identical in both cell types. Gene Ontology (GO) analysis of these commonly r

SUBMITTER: Geyer H 

PROVIDER: S-EPMC4736114 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature