Extrathoracic investigation in adult patients with isolated pulmonary langerhans cell histiocytosis.

ABSTRACT:

Background

An important objective on diagnosis of patients with Langerhans cell histiocytosis (LCH) is to determine the extent of disease. However, whether systematic extrathoracic investigation is needed in adult patients with clinically isolated pulmonary LCH (PLCH) has not been evaluated.

Methods

In this prospective, multicentre study, 54 consecutive patients with newly diagnosed clinically isolated PLCH were systematically evaluated at inclusion by bone imaging and blood laboratory testing to search for subclinical extrapulmonary LCH involvement. The patients were followed over a 2-year period. At each visit, they were asked about the presence of extrapulmonary manifestations of LCH.

Results

In the absence of bone symptoms, the skeletal X-ray survey results were n

SUBMITTER: Tazi A 

PROVIDER: S-EPMC4736248 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature