Neural correlates of working memory training in HIV patients: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Potent combined antiretroviral therapy decreased the incidence and severity of HIV-associated neurocognitive disorders (HAND); however, no specific effective pharmacotherapy exists for HAND. Patients with HIV commonly have deficits in working memory and attention, which may negatively impact many other cognitive domains, leading to HAND. Since HAND may lead to loss of independence in activities of daily living and negative emotional well-being, and incur a high economic burden, effective treatments for HAND are urgently needed. This study aims to determine whether adaptive working memory training might improve cognitive functions and neural network efficiency and possibly decrease neuroinflammation. This study also aims to assess whether subjects with the LMX1A-rs4657412

SUBMITTER: Chang L 

PROVIDER: S-EPMC4736265 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature