Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model.

ABSTRACT:

Introduction

Development of an animal model of rheumatoid arthritis-interstitial lung disease (RA-ILD) and improved knowledge of the pathogenesis of RA-ILD may facilitate earlier diagnosis and the development of more effective targeted therapies.

Methods

Adult male Wistar rats were studied in an adjuvant arthritis (AA) model induced by the injection of Freund's complete adjuvant (FCA). Rats were sacrificed on days 7, 14, 21, and 28 after FCA injection. Lung tissue was obtained for histopathological examination and evaluation of Caveolin-1 (Cav-1) and transforming growth factor-β (TGF-β1) protein expression levels.

Results

Pulmonary inflammation was evident in lung tissue from day 21 after FCA injection. Inflammation and mild fibrosis were observed in lung tissue on da

SUBMITTER: Song LN 

PROVIDER: S-EPMC4736313 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature