Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases.

ABSTRACT: Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some

SUBMITTER: Ramirez A 

PROVIDER: S-EPMC4736365 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature