Ki67--An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity.

ABSTRACT:

Background and objectives

Due to contradictious findings of previous studies regarding Ki67's value in gastric cancer (GC), we reevaluated the expression of Ki67 in whole tissue sections (WTS) and tissue microarrays (TMAs) of GC testing the following hypotheses: does Ki67 show intratumoral heterogeneity; are TMAs representative in the determination of the Ki67 proliferation index (PI); is the Ki67 PI subject to an intralaboratory variability; and is the Ki67 PI related to clinico-pathological patient characteristics and/or prognostically relevant in GC.

Methods

Corresponding WTS and TMAs samples from 315 GCs were stained immunohistochemically. The Ki67 PI evaluated on WTS was correlated with the Ki67 PI evaluated on TMAs, sample age, clinico-pathological characteristics, and

SUBMITTER: Boger C 

PROVIDER: S-EPMC4736456 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature