Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population.

ABSTRACT:

Background

The genetic contribution to complex diseases or traits, including cardio-metabolic traits, has been elucidated recently by large-scale genome-wide association studies. These genome-wide association studies have indicated that most pleiotropic loci contain genes associated with lipids. Clinically, lipid related abnormalities are strongly associated with other diseases such as type 2 diabetes, coronary artery disease and hypertension. The aim of this study was to evaluate the shared genetic background of lipids and other cardio-metabolic traits.

Methods

We conducted meta-analyses of the association between 157 published lipid-associated loci and 10 cardio-metabolic traits in 14,028 Korean individuals genotyped using the Exome chip (Illumina HumanExome BeadChip). We

SUBMITTER: Kim YK 

PROVIDER: S-EPMC4736473 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature