Mining integrated semantic networks for drug repositioning opportunities.

ABSTRACT: Current research and development approaches to drug discovery have become less fruitful and more costly. One alternative paradigm is that of drug repositioning. Many marketed examples of repositioned drugs have been identified through serendipitous or rational observations, highlighting the need for more systematic methodologies to tackle the problem. Systems level approaches have the potential to enable the development of novel methods to understand the action of therapeutic compounds, but requires an integrative approach to biological data. Integrated networks can facilitate systems level analyses by combining multiple sources of evidence to provide a rich description of drugs, their targets and their interactions. Classically, such networks can be mined manually where a skilled person i

SUBMITTER: Mullen J 

PROVIDER: S-EPMC4736989 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature