Beegle: from literature mining to disease-gene discovery.

ABSTRACT: Disease-gene identification is a challenging process that has multiple applications within functional genomics and personalized medicine. Typically, this process involves both finding genes known to be associated with the disease (through literature search) and carrying out preliminary experiments or screens (e.g. linkage or association studies, copy number analyses, expression profiling) to determine a set of promising candidates for experimental validation. This requires extensive time and monetary resources. We describe Beegle, an online search and discovery engine that attempts to simplify this process by automating the typical approaches. It starts by mining the literature to quickly extract a set of genes known to be linked with a given query, then it integrates the learning methodol

SUBMITTER: ElShal S 

PROVIDER: S-EPMC4737179 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature