A computational method for studying the relation between alternative splicing and DNA methylation.

ABSTRACT: Alternative splicing is an important mechanism in eukaryotes that expands the transcriptome and proteome significantly. It plays an important role in a number of biological processes. Understanding its regulation is hence an important challenge. Recently, increasing evidence has been collected that supports an involvement of intragenic DNA methylation in the regulation of alternative splicing. The exact mechanisms of regulation, however, are largely unknown, and speculated to be complex: different methylation profiles might exist, each of which could be associated with a different regulation mechanism. We present a computational technique that is able to determine such stable methylation patterns and allows to correlate these patterns with inclusion propensity of exons. Pattern detection i

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC4737180 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature