A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain.

ABSTRACT:

Background

Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients. The purpose of this study is to identify genetic factors contributing to this type of pain in a general diabetic population.

Method

We accessed the Genetics of Diabetes Audit and Research Tayside (GoDARTS) datasets that contain prescription information and monofilament test results for 9439 diabetic patients, among which 6927 diabetic individuals were genotyped by Affymetrix SNP6.0 or Illumina OmniExpress chips. Cases of neuropathic pain were defined as diabetic patients with a prescription history of at least one of five drugs specifically indicated for the treatment of neuropathic pain and in whom monofilament test r

SUBMITTER: Meng W 

PROVIDER: S-EPMC4737240 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature