Epilepsy in adults with mitochondrial disease: A cohort study.

ABSTRACT:

Objective

The aim of this work was to determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease.

Methods

We prospectively recruited a cohort of 182 consecutive adult patients attending a specialized mitochondrial disease clinic in Newcastle upon Tyne between January 1, 2005 and January 1, 2008. We then followed this cohort over a 7-year period, recording primary outcome measures of occurrence of first seizure, status epilepticus, stroke-like episode, and death.

Results

Overall prevalence of epilepsy in the cohort was 23.1%. Mean age of epilepsy onset was 29.4 years. Prevalence varied widely between genotypes, with several genotypes having no cases of epilepsy, a prevalence of 34.9% in the most common genotype (m.3243A>G mutation

SUBMITTER: Whittaker RG 

PROVIDER: S-EPMC4737309 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature