Phospholipid Scramblases.

ABSTRACT: The distribution of phospholipid types between the two leaflets of a membrane bilayer is a controlled feature of membrane structure. One of the two membrane catalytic activities governing this distribution randomizes the composition of the two leaflets-the phospholipid scramblases. Two proteins (Xkr8 and TMEM16F) required for the activation of these activities have been identified. One of these proteins (TMEM16F) is quite clearly a scramblase itself and provides insight into the mechanism by which transbilayer phospholipid movement is facilitated.

SUBMITTER: Williamson P 

PROVIDER: S-EPMC4737519 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature