Germline Mutation of the CCK Receptor: A Novel Biomarker for Pancreas Cancer.

ABSTRACT:

Objectives

Today, genetic biomarkers have been demonstrated to play an important role in identifying at-risk subjects for familial or inherited cancers. We have identified a single-nucleotide polymorphism (SNP) that results in missplicing of the cholecystokinin (CCK) receptor gene and expressing a larger mutated receptor in pancreatic cancer. The purpose of this study was to evaluate the significance and specificity of this SNP as a potential biomarker in patients with pancreatic cancer compared with other gastrointestinal (GI) cancers that also have CCK receptors.

Methods

DNA was isolated and genotyped for the CCK receptor SNP from frozen tumor tissue from banked specimens of patients with pancreas, gastric, or colon cancer and from human cancer cell lines. Genotype and all

SUBMITTER: Alsubai J 

PROVIDER: S-EPMC4737870 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature