Low-dose aspirin use does not diminish the immune response to monovalent H1N1 influenza vaccine in older adults.

ABSTRACT: Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit antibody production by peripheral blood mononuclear cells; one consequence of this could be decreased effectiveness of vaccines in NSAID users. Because many older adults use low-dose aspirin for primary or secondary prevention of coronary events, any inhibitory effect of aspirin on vaccine immune response could reduce the benefits of vaccination programmes in older adults. We tested whether immune response to vaccination differed between users vs. non-users of low-dose aspirin, using data from four randomized trials of monovalent 2009 pandemic influenza A(H1N1) vaccine. Geometric mean haemagglutination inhibition antibody titres were not significantly lower in low-dose aspirin users compared to non-users. Our results provide reassu

SUBMITTER: Jackson ML 

PROVIDER: S-EPMC4737981 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature