Trajectories of suicidal ideation in depressed older adults undergoing antidepressant treatment.

ABSTRACT: Suicide is a public health concern in older adults. Recent cross sectional studies suggest that impairments in executive functioning, memory and attention are associated with suicidal ideation in older adults. It is unknown whether these neuropsychological features predict persistent suicidal ideation. We analyzed data from 468 individuals ≥ age 60 with major depression who received venlafaxine XR monotherapy for up to 16 weeks. We used latent class growth modeling to classify groups of individuals based on trajectories of suicidal ideation. We also examined whether cognitive dysfunction predicted suicidal ideation while controlling for time-dependent variables including depression severity, and age and education. The optimal model using a zero inflated Poisson link classified individuals

SUBMITTER: Kasckow J 

PROVIDER: S-EPMC4738173 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature