Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer.

ABSTRACT:

Purpose

Recent data suggest that neuroendocrine signaling may influence progression in some cancers. We aimed to determine whether genes within the five major stress-related signaling pathways are differentially expressed in tumor tissue when comparing prostate cancer patients with lethal and nonlethal disease.

Experimental design

We measured mRNA expression of 51 selected genes involved in predetermined stress-related signaling pathways (adrenergic, glucocorticoid, dopaminergic, serotoninergic, and muscarinic systems) in tumor tissue and normal prostate tissue collected from prostate cancer patients in the Physicians' Health Study (n = 150; n = 82 with normal) and the Health Professionals Follow-Up Study (n = 254; n = 120 with normal). We assessed differences in pathway exp

SUBMITTER: Lu D 

PROVIDER: S-EPMC4738177 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature