Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients.

ABSTRACT: Tumors act systemically to sustain cancer progression, affecting the physiological processes in the host and triggering responses in the blood circulating cells. In this study, we explored blood transcriptional patterns of patients with two subtypes of HER2 negative breast cancers, with different prognosis and therapeutic outcome. Peripheral blood samples from seven healthy female donors and 29 women with breast cancer including 14 triple-negative breast cancers and 15 hormone-dependent breast cancers were evaluated by microarray. We also evaluated the stroma in primary tumors. Transcriptional analysis revealed distinct molecular signatures in the blood of HER2- breast cancer patients according to ER/PR status. Our data showed the implication of immune signaling in both breast cancer subty

SUBMITTER: Balacescu O 

PROVIDER: S-EPMC4738716 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature