"Hit-and-Run" transcription: de novo transcription initiated by a transient bZIP1 "hit" persists after the "run".

ABSTRACT:

Background

Dynamic transcriptional regulation is critical for an organism's response to environmental signals and yet remains elusive to capture. Such transcriptional regulation is mediated by master transcription factors (TF) that control large gene regulatory networks. Recently, we described a dynamic mode of TF regulation named "hit-and-run". This model proposes that master TF can interact transiently with a set of targets, but the transcription of these transient targets continues after the TF dissociation from the target promoter. However, experimental evidence validating active transcription of the transient TF-targets is still lacking.

Results

Here, we show that active transcription continues after transient TF-target interactions by tracking de novo synthesis of RNAs

SUBMITTER: Doidy J 

PROVIDER: S-EPMC4738784 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature