ALP & FALP: C++ libraries for pairwise local alignment E-values.

ABSTRACT:

Motivation

Pairwise local alignment is an indispensable tool for molecular biologists. In real time (i.e. in about 1 s), ALP (Ascending Ladder Program) calculates the E-values for protein-protein or DNA-DNA local alignments of random sequences, for arbitrary substitution score matrix, gap costs and letter abundances; and FALP (Frameshift Ascending Ladder Program) performs a similar task, although more slowly, for frameshifting DNA-protein alignments.

Availability and implementation

To permit other C++ programmers to implement the computational efficiencies in ALP and FALP directly within their own programs, C++ source codes are available in the public domain at http://go.usa.gov/3GTSW under 'ALP' and 'FALP', along with the standalone programs ALP and FALP.

Contact

spo

SUBMITTER: Sheetlin S 

PROVIDER: S-EPMC4739181 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature