Effects of a dietary intervention with conjugated linoleic acid on immunological and metabolic parameters in children and adolescents with allergic asthma--a placebo-controlled pilot trial.

ABSTRACT:

Background

Circumstantial evidence suggests that conjugated linoleic acid (CLA) beneficially modulates immune function in allergic subjects. C9,t11-CLA, naturally occurring in ruminant fats, is suggested to be the effective isomer. In contrast, for the t10,c12-CLA isomer, which is naturally found only in traces but usually constitutes a relevant part in commercial CLA mixtures, adverse effects have been reported. Aim of this study was to assess putative immunomodulatory effects of highly enriched c9,t11-CLA in allergic subjects. To our best knowledge, our study is the first in that a CLA preparation was used for such purpose which was free of t10,c12-CLA.

Design

Twenty-nine asthmatic children and adolescents (age 6-18 y) with diagnosed allergic sensitization against grass po

SUBMITTER: Jaudszus A 

PROVIDER: S-EPMC4739392 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature