Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal.

ABSTRACT: Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells susceptible to viral cytopathic effects and immune clearance. We identified the BAF chromatin remodeling complex as a key player required for maintenance of HIV-1 latency, highlighting its potential as a molecular target for inhibition in latency reversal. Here, we screened a recently identified panel of small molecule inhibitors of BAF (BAFi's) for potential to activate latent HIV-1. Latency reversal was strongly induced by BAFi's Caffeic Acid Phenethyl Ester and Pyrimethamine, two molecules previously characterized for clinical application

SUBMITTER: Stoszko M 

PROVIDER: S-EPMC4739437 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature