Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility.

ABSTRACT:

Background

The standard therapy for women with unexplained infertility is gonadotropin or clomiphene citrate. Ovarian stimulation with letrozole has been proposed to reduce multiple gestations while maintaining live birth rates.

Methods

We enrolled couples with unexplained infertility in a multicenter, randomized trial. Ovulatory women 18 to 40 years of age with at least one patent fallopian tube were randomly assigned to ovarian stimulation (up to four cycles) with gonadotropin (301 women), clomiphene (300), or letrozole (299). The primary outcome was the rate of multiple gestations among women with clinical pregnancies.

Results

After treatment with gonadotropin, clomiphene, or letrozole, clinical pregnancies occurred in 35.5%, 28.3%, and 22.4% of cycles, and live bi

SUBMITTER: Diamond MP 

PROVIDER: S-EPMC4739644 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature