Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation.

ABSTRACT: Spatial memory depends on the hippocampus, which is particularly vulnerable to aging. This vulnerability has implications for the impairment of navigation capacities in older people, who may show a marked drop in performance of spatial tasks with advancing age. Contemporary understanding of long-term memory formation relies on molecular mechanisms underlying long-term synaptic plasticity. With memory acquisition, activity-dependent changes occurring in synapses initiate multiple signal transduction pathways enhancing protein turnover. This enhancement facilitates de novo synthesis of plasticity related proteins, crucial factors for establishing persistent long-term synaptic plasticity and forming memory engrams. Extensive studies have been performed to elucidate molecular mechanisms of mem

SUBMITTER: Borovok N 

PROVIDER: S-EPMC4739671 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature