MASH Suite Pro: A Comprehensive Software Tool for Top-Down Proteomics.

ABSTRACT: Top-down mass spectrometry (MS)-based proteomics is arguably a disruptive technology for the comprehensive analysis of all proteoforms arising from genetic variation, alternative splicing, and posttranslational modifications (PTMs). However, the complexity of top-down high-resolution mass spectra presents a significant challenge for data analysis. In contrast to the well-developed software packages available for data analysis in bottom-up proteomics, the data analysis tools in top-down proteomics remain underdeveloped. Moreover, despite recent efforts to develop algorithms and tools for the deconvolution of top-down high-resolution mass spectra and the identification of proteins from complex mixtures, a multifunctional software platform, which allows for the identification, quantitation, a

SUBMITTER: Cai W 

PROVIDER: S-EPMC4739683 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature