Automatic Segmentation of Mechanically Inhomogeneous Tissues Based on Deformation Gradient Jump.

ABSTRACT: Variations in properties, active behavior, injury, scarring, and/or disease can all cause a tissue's mechanical behavior to be heterogeneous. Advances in imaging technology allow for accurate full-field displacement tracking of both in vitro and in vivo deformation from an applied load. While detailed strain fields provide some insight into tissue behavior, material properties are usually determined by fitting stress-strain behavior with a constitutive equation. However, the determination of the mechanical behavior of heterogeneous soft tissue requires a spatially varying constitutive equation (i.e., one in which the material parameters vary with position). We present an approach that computationally dissects the sample domain into many homogeneous subdomains, wherein subdomain boundaries

SUBMITTER: Witzenburg CM 

PROVIDER: S-EPMC4739827 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature