A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial of Aminophylline to Prevent Acute Kidney Injury in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass.

ABSTRACT:

Objectives

Acute kidney injury occurs commonly in children following congenital cardiac surgery with cardiopulmonary bypass and has been associated with increased morbidity and mortality. Aminophylline, a methylxanthine nonselective adenosine receptor antagonist, has been effective in the management of acute kidney injury in certain populations. This study sought to determine whether postoperative administration of aminophylline attenuates acute kidney injury in children undergoing congenital cardiac surgery with cardiopulmonary bypass.

Design

Single-center, double-blinded, placebo-controlled, randomized clinical trial.

Setting

Tertiary center, pediatric cardiovascular ICU.

Patients

A total of 144 children after congenital heart surgery with cardiopulmonary byp

SUBMITTER: Axelrod DM 

PROVIDER: S-EPMC4740222 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature