Vascular and autonomic dysregulation in primary open-angle glaucoma.

ABSTRACT:

Purpose of review

The purpose of this review is to discuss whether vascular dysfunction and autonomic dysfunction are related to primary open-angle glaucoma stratified by the intraocular pressure (IOP) level.

Recent findings

Patients with primary open angle glaucoma (POAG) across the spectrum of IOP exhibit a variety of ocular and nonocular vascular abnormalities. Interestingly, common genetic variation in nitric oxide synthase 3 (NOS3) and the caveolin 1/caveolin 2 (CAV1/CAV2) genomic regions, which code for proteins involved in setting vascular tone, are associated with POAG. These markers seem to stratify with POAG subtypes stratified by sex or pattern of initial visual field loss and not by IOP level. Overall, it is clear that there is also cardiovascular autonomic dysfu

SUBMITTER: Pasquale LR 

PROVIDER: S-EPMC4740225 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature